全文获取类型
收费全文 | 9307篇 |
免费 | 1031篇 |
国内免费 | 159篇 |
专业分类
耳鼻咽喉 | 23篇 |
儿科学 | 164篇 |
妇产科学 | 60篇 |
基础医学 | 924篇 |
口腔科学 | 214篇 |
临床医学 | 1459篇 |
内科学 | 1668篇 |
皮肤病学 | 38篇 |
神经病学 | 329篇 |
特种医学 | 198篇 |
外国民族医学 | 1篇 |
外科学 | 2286篇 |
综合类 | 1709篇 |
预防医学 | 263篇 |
眼科学 | 105篇 |
药学 | 707篇 |
8篇 | |
中国医学 | 177篇 |
肿瘤学 | 164篇 |
出版年
2024年 | 21篇 |
2023年 | 239篇 |
2022年 | 339篇 |
2021年 | 484篇 |
2020年 | 480篇 |
2019年 | 448篇 |
2018年 | 433篇 |
2017年 | 368篇 |
2016年 | 336篇 |
2015年 | 329篇 |
2014年 | 605篇 |
2013年 | 542篇 |
2012年 | 497篇 |
2011年 | 547篇 |
2010年 | 402篇 |
2009年 | 430篇 |
2008年 | 446篇 |
2007年 | 450篇 |
2006年 | 377篇 |
2005年 | 333篇 |
2004年 | 300篇 |
2003年 | 217篇 |
2002年 | 167篇 |
2001年 | 171篇 |
2000年 | 143篇 |
1999年 | 132篇 |
1998年 | 113篇 |
1997年 | 121篇 |
1996年 | 80篇 |
1995年 | 102篇 |
1994年 | 73篇 |
1993年 | 87篇 |
1992年 | 95篇 |
1991年 | 72篇 |
1990年 | 56篇 |
1989年 | 59篇 |
1988年 | 61篇 |
1987年 | 48篇 |
1986年 | 34篇 |
1985年 | 55篇 |
1984年 | 36篇 |
1983年 | 35篇 |
1982年 | 39篇 |
1981年 | 25篇 |
1980年 | 22篇 |
1979年 | 11篇 |
1977年 | 11篇 |
1976年 | 6篇 |
1975年 | 7篇 |
1973年 | 4篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Sau Lai Lee Philip Thomas Jane Hecker Jeffrey Faunt Michael Fenech 《Environmental and molecular mutagenesis》2015,56(1):32-40
Loss of genome integrity may be associated with increased risk for neurodegenerative disease. The aim of this study was to investigate whether mild cognitive impairment (MCI) or Alzheimer's disease (AD) individuals have increased DNA damage relative to age‐ and gender‐ matched controls using the cytokinesis‐block micronucleus cytome (CBMN‐Cyt) assay. DNA damage was measured as micronuclei (MN), nucleoplasmic bridges (NPB), and nuclear buds (NBUD) in binucleated cells. The assay was performed on blood samples from 80 participants consisting of (i) MCI cases (N = 20) and age‐ and gender‐ matched controls (N = 20), and (ii) AD cases (N = 20) and age‐ and gender‐ matched controls (N = 20). There was a significant increase in MCI NBUD frequency (P = 0.006) relative to controls, which was also observed in male (P = 0.03) and female (P = 0.04) subgroups. For AD cases, there were no significant differences in assay biomarkers relative to controls. There was a significant negative correlation between Mini Mental State Examination (MMSE) and (i) MN in all controls, (R = ?0.3, P = 0.04), and AD cases (R = ?0.4, P = 0.03), (ii) NPB in all controls, (R = ?0.4, P = 0.006) and AD cases (R = ?0.5, P = 0.01), and (iii) NBUD in MCI cases (R = ?0.5, P = 0.007) and AD cases (R = ?0.7, P = 0.0002). The results suggest that an increase in lymphocyte CBMN‐Cyt DNA damage biomarkers may be associated with cognitive decline. Environ. Mol. Mutagen. 56:32–40, 2015. © 2014 Wiley Periodicals, Inc. 相似文献
32.
The aim of this study was to evaluate the safety and efficacy of
ultrasound-guided ilioinguinal/iliohypogastric nerve block (IINB) in pediatric
patients undergoing same-day inguinal region surgery. Ninety patients aged
4–6 years, ASA levels I–II, were randomly divided into three groups: U, T, or C
(n = 30 each). After basic anesthesia, patients
in group U underwent ultrasound-guided IINB, those in group T underwent traditional
Schulte-Steinberg IINB, and those in group C (controls) received intravenous
anesthesia (ketamine-propofol) only. Patients who remained sensitive to
intraoperative stimuli received additional intravenous doses of 1 mg/kg ketamine.
Heart rate (HR), mean arterial pressure (MAP), and oxygen saturation
(SPO2) were recorded upon entering the operating room (T0),
at skin incision (T1), while pulling the hernia sac (T2), during skin closing (T3),
and upon awakening (T4) at recovery. HR and MAP at T1, T2, and T4 were higher in
group C than those in the other two groups, and recovery time in group C was
significantly prolonged (P < 0.05). Group U
required significantly lower quantities and frequency of ketamine injection, and
pain scores in group U during awakening were lower than those in the other two
groups (P < 0.05). Ultrasound-guided IINB
provided an improved nerve block effect and postoperative analgesia, reduced the
amount of local anesthetic required, facilitated more rapid postoperative recovery,
and was a safe and effective method of anesthesia. 相似文献
33.
Jung-Woo Shim Jemin Ko Chul-Seung Lee Do-Sang Lee Jaesik Park Hyung Mook Lee Yong-Suk Kim Young Eun Moon Sang Hyun Hong Min Suk Chae 《Asian journal of surgery / Asian Surgical Association》2021,44(1):254-261
BackgroundThis study investigated the optimal timing of analgesic transversus abdominis plane (TAP) block in the operating room for better recovery quality using the Korean version of the Quality of Recovery-40 (QoR-40K) questionnaire in patients who had undergone open inguinal herniorrhaphy.MethodsThis single-centre, prospective randomised controlled study included adult male patients who had an ASA physical status of I–II. A total of 80 patients were analysed. The patients were randomly assigned and classified into pre-incisional TAP (pre-TAP) block (n = 40) and post-incisional TAP (post-TAP) block (n = 40) groups. The quality of postoperative functional recovery and complications were compared between the two groups during 24 h postoperatively.ResultsPreoperative findings of the two groups were comparable. The global QoR-40K score was higher in the pre-TAP group than in the post-TAP group. Among sub-dimensions, scores of physical comfort and pain were higher in the pre-TAP group than in the post-TAP group. In the post-anaesthesia care unit, the pre-TAP group showed lower pain scores than the post-TAP block group. There was no severe pain in the pre-TAP group, but two patients (5.0%) in the post-TAP block group suffered severe pain. The pre-TAP group required lower doses of IV rescue opioid in the PACU than the post-TAP group. All patients were discharged from hospital on postoperative day 1 without surgical complications.ConclusionsThe timing of analgesic TAP block may be of clinical importance to prevent postoperative pain and to improve the quality of early patient recovery following open inguinal herniorrhaphy. 相似文献
34.
35.
36.
Peter Marhofer Malachy Columb Phil M. Hopkins Manfred Greher Daniela Marhofer Max R. Levi Bienzle Markus Zeitlinger 《British journal of anaesthesia》2019,122(4):525-531
Background
The efficacy of dexamethasone in extending the duration of local anaesthetic block is uncertain. In a randomised controlled triple blind crossover study in volunteers, we tested the hypothesis that neither i.v. nor perineurally administered dexamethasone prolongs the sensory block achieved with ropivacaine.Methods
Ultrasound-guided ulnar nerve blocks (ropivacaine 0.75% wt/vol, 3 ml, with saline 1 ml with or without dexamethasone 4 mg) were performed on three occasions in 24 male volunteers along with an i.v. injection of saline 1 ml with or without dexamethasone 4 mg. The combinations of saline and dexamethasone were as follows: control group, perineural and i.v. saline; perineural group, perineural dexamethasone and i.v. saline; i.v. group, perineural saline and i.v. dexamethasone. Sensory block was measured using a VAS in response to pinprick testing. The duration of sensory block was the primary outcome and time to onset of sensory block the secondary outcome.Results
All 24 subjects completed the trial. The median [inter-quartile range (IQR)] duration of sensory block was 6.87 (5.85–7.62) h in the control group, 7.37 (5.78–7.93) h in the perineural group and 7.37 (6.10–7.97) h in the i.v. group (P=0.61). There was also no significant difference in block onset time between the three groups.Conclusion
Dexamethasone 4 mg has no clinically relevant effect on the duration of sensory block provided by ropivacaine applied to the ulnar nerve.Clinical trial registration
DRKS, 00014604; EudraCT, 2018-001221-98. 相似文献37.
Alessandro De Cassai Tommaso Tonetti Helmut Galligioni Carlo Ori 《Brazilian Journal of Anesthesiology》2019,69(1):95-98
Background and objective
Erector spinae plane block is a valid technique to provide simultaneously analgesia for combined thoracic and abdominal surgery.Case report
A patient underwent open esophagectomy followed by reconstructive esophagogastroplasty but refused thoracic epidural analgesia; a multi‐modal analgesia with a multiple erector spinae plane block was then planned. Three erector spinae plane catheters (T5 and T10 on the right side and T9 on the left side) for continuous analgesia were placed before surgery. During the first 48 h pain was never reported in the thoracic area but the patient reported multiple times to feel a pain well localized in epigastrium, but never localized in any other abdominal quadrant.Discussion
Erector spinae plane block is a valid technique to provide analgesia simultaneously for combined thoracic and abdominal surgery and could be a valid alternative strategy if the use of epidural analgesia is contraindicated. 相似文献38.
39.
40.
Joseph Marino Giles Scuderi Oonagh Dowling Rena Farquhar Bridget Freycinet Frank Overdyk 《The Journal of arthroplasty》2019,34(3):495-500